PLA-tetracycline 복합체가 코팅된 금 나노로드-티타니아 나노튜브의 적외선레이저 유도 항균능 및 생체적합성 평가
Infrared LASER mediated antibacterial activity and biocompatibility of PLA-tetracycline complexes coated gold nanorod-titania nanotubes
문경숙, 배지명, 오승한,
소속 상세정보
문경숙 ( Mon Kyoung-Sook ) - 원광대학교 치과대학 치과생체재료학교실
배지명 ( Bae Ji-Myung ) - 원광대학교 치과대학 치과생체재료학교실
오승한 ( Oh Seung-Han ) - 원광대학교 치과대학 치과생체재료학교실
KMID : 1035320150420040307
Abstract
In this study, we coated poly-lactic acid(PLA)-tetracycline complexes to the surface of gold nanorod incorporated titania nanotubes with different concentration (0.1 - 1.0 wt%) of PLA-tetracycline complexes and estimated their infrared LASER mediated antibacterial effect and biocompatibility. The results of Transmission electron microscopy(TEM) and UV-Vis spectrophotometer indicated that gold nanorods had the 1 to 4 of aspect ratio and showed the highest absorbance at the wavelength of 800 nm. Energy Dispersive X-ray Spectrometer(EDX) analysis showed that the amounts of gold nanorods coated on titania nanotubes were approximately 8 wt%. MTT assay resulted that the cell viability of all experimental groups were significantly higher than 70% (minimum requirement of biocompatibility) after 24 and 48 hrs of incubation times. Antibacterial test resulted that all experimental groups showed antibacterial activity against Streptococcus mutans regardless of the concentration of PLA-tetracycline complexes, and the annihilation of Streptococcus mutans were accelerated by infrared LASER irradiation. Therefore, infrared LASER mediated antibacterial activity of gold nanorods is expected to be more effective in the field of implant fabrication due to the invisible antibacterial effect of gold nanorods via infrared LASER irradiation.
키워드
Gold nanorods(GNRs); Titania nanotubes; Infrared LASER; Biocompatibility
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